Bioactive Small Molecules
Cayman Chemical BAY-1895344hydrochlorIde 10mg
An ATR inhibitor; inhibits proliferation in a panel of human tumor cell lines (mean IC50 = 78 nM); halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models; exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases
Cayman Chemical ANTIBODY Zngeron 25g
A phenolic ketone; scavenges DPPH radicals in a cell-free assay (EC50 = 41.6 μmol); prevents myocardial expression of TNF-α, IL-1β, and IL-6 in rats following isoproterenol-induced myocardial infarction at 6 mg/kg per day; decreases 1,2-dimethylhydrazine-induced tumor incidence by 67% and aberrant crypt foci formation by 68.85% in rats at 20 mg/kg per day; decreases E. coli heat-labile enterotoxin-induced fluid accumulation in the ileal loop of mice at 10 mM
Cayman Chemical ANTIBODY DLAC 250mg
A detergent used to solubilize membrane proteins; synthesized from lactobionic acid; CMC = 1.3 mM
Cayman Chemical L-CystathIonIn 5mg
A precursor of cysteine formed in the methionine transsulfuration pathway; deficiency can indicate the presence of metabolic disorders such as cystathioninuria
Medchemexpress LLC CD96 Human HEK293 10ug
CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells CD96 Protein Human (HEK293 His) is the recombinant human-derived CD96 protein expressed by HEK293 with C-6 His labeled tag
Cayman Chemical TGR5 Receptr AgonIst 25mg
An agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays); stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM); increases GLP-1 secretion and decreases glucose levels in the hepatic portal vein in dogs at 1 mg/kg when administered in combination with glucose; inhibits the CYP isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively)
TARGETMOL CHEMICALS INC POZIOTINIB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Poziotinib (NOV120101)(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s 3/5/23 nM). purity: 99%
Cayman Chemical ANTIBODY LDC-4297 10mg
A CDK7 inhibitor (IC50 = 50s = >10, >10, and 1.71 μM); inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively); induces apoptosis in A549, HeLa, and HCT116 cancer cells from 10-100 nM; inhibits HCMV replication in human fibroblasts (EC50 = 24.5 nM); reduces replication of various viruses (EC50s = 0.02-1.13 μM)
Cayman Chemical ANTIBODY 15-OxoETE 100ug
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE.{2793} Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.
Cayman Chemical ANTIBODY SCH 28080 50mg
A K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM); effective against gastric H+/K+-ATPases from a variety of species and can inhibit some colonic H+/K+-ATPases
TARGETMOL CHEMICALS INC CPI203 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50 37 nM for BRD4). purity: 99%
![Medchemexpress LLC Methyl (2S)-2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propanoate | 778624-05-8 | >98.0% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230268.png-250.jpg)
Medchemexpress LLC Methyl (2S)-2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propanoate | 778624-05-8 | >98.0% | 5 MG
LDL-IN-2 is a small-molecule research compound reported to act as an antioxidant that prevents copper-mediated low-density lipoprotein (LDL) oxidation. It is supplied for research use only and is typically provided as a solid with reported purity greater than 98% and solubility in DMSO.
- Antioxidant activity against copper-mediated LDL oxidation.
- Reported purity greater than 98%.
- Soluble in DMSO; suitable for common in vitro formulations.
- Available in small research quantities such as 5 mg and 10 mg.
- Intended for research use only, not for human or diagnostic use.
TARGETMOL CHEMICALS INC YLF-466D 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. YLF-466D (C24) is a newly developed AMPK activator which inhibits platelet aggregation. purity: 98%
Cayman Chemical ANTIBODY14 15-EET 100UG
An arachidonic acid metabolite; formed via epoxidation of arachidonic acid by cytochrome P450; prevents increases in LTB4, ICAM-1, and CCL2 induced by oxidized LDL in primary RPAECs at 1 μM; induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM); reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by LAD occlusion at 0.128 mg/kg prior to occlusion or reperfusion
Medchemexpress LLC Recombinant mouse interleukin-15 (His-tag) | >95.0% | 50UG
Recombinant mouse interleukin-15 (IL-15) is an animal-free, His-tagged cytokine produced in Escherichia coli and supplied for cell culture research applications. The protein corresponds to the mature mouse IL-15 sequence (UniProt P48346, residues N49-S162) and is provided as a small-scale vial for in-lab assays.
- Animal-free recombinant IL-15 with N-terminal His tag.
- Produced in Escherichia coli for consistent lot-to-lot supply.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Approximate molecular weight 14.06 kDa.
- Supplied in a 50 μg vial suitable for cell culture use.
- Sequence corresponds to UniProt P48346 residues N49-S162.